ФГБУ «ВНИИИМТ» Росздравнадзора – национальный испытательный институт России.

Prospects in treatment and preventive maintenance of hereditary and congenital diseases

Bleskin B.I., Trushkin N.S., Juromskiy V.M., Stepanischev V.M.

FGU «VNIIIMT» Roszdravnadzora

National Research Nuclear University "MEPhI"

According to the World organisation of public health services (CART), now more than 5000 illnesses are caused by genetic infringements. 5-8 % of newborns are born with congenital defects; 40 % of early children's death rate and 50 % of abortions are caused by a genetic pathology. As a matter of fact there is epidemic of a genetic pathology.

From the end of a XIX-th century studying of hereditary and congenital diseases is assigned to genetics. In treatment and preventive maintenance of this pathology of hope are assigned to genno-engineering therapy. By a realisation technique - genno-engineering therapy is subdivided on replaceable and корригирующую. Carrying over of genes to a somatic cage is carried out with use of viruses (in 90 %) or through physical methods of delivery.

         Hereditary and congenital defects are always tragedy both for the patient and for relatives. This tragedy and for doctors who try to facilitate existence of the patient, knowing the subsequent negative forecast for its posterity. It is a situation conflicts to a following fact: at the person (conditionally), born in 1965 - two parents, in following generation of 4 more ancestors, in 1215 33554432 ancestors, and in 1195 67088364 ancestors. It follows from this that the genetic component of our contemporaries should possess high potential.

The person - one of three millions kinds of biosphere of the Earth. The biological structure of the person for last has not changed 11000. Evolution is realised through cephalization - development of mental faculties. The health status represents dynamic balance in this interspecific struggle. Thus the person radiates also itself is exposed to various kinds of radiations. The illness condition arises when this dynamic balance is broken, leading to a functional and organic pathology, and at essential infringements to death.

When this struggle proceeds in the sharp form - name acute infectious diseases. But most often struggle proceeds in the latent form, with a so-called slow infection. And medical workers having clinical displays of any disease, usually do not connect it or do not give an actual meaning to influence on the person of a slow (virus) infection. It is promoted by the standard classification in the modern medicine, confirmed a CART, all diseases on two kinds:

1) the infectious;

2) not infectious.

         This division, in our opinion, withdraws from true judgement of the deep processes causing disharmony - illness of the person as display of interspecific struggle, contradicts world - weakens actions on preventive maintenance and rehabilitation of people and protection of health of medical figures. It confirms the medical statistican: in the USA where the most developed modern medicine, average life expectancy of physicians for 18 years is less than average on the country.

In the light of disease consideration as interspecific struggle of a human body for the biological niche, infringement in genom with a congenital pathology in our opinion carries patients not primary, but secondary character: the infection, sharp or slow, in a consequence of direct influence on an embryo, on mother, and also toxic and power information influence on exchange and immune processes, leads to infringement of function and structure of the genetic device with the subsequent formation of congenital defects, and also transfer by right of succession to the subsequent posterity of this adapted infection. In the mechanism of formation of these deviations it is necessary to pay attention to influence on endocrine system and especially on insulin system since insulin carries out adjustment of carbohydrate, albuminous, fatty, mineral object, transfer of oxygen to fabrics, rheology blood and immunity. Infringement insulin systems comes to light usually at defeat by viruses of 70-80 % β - pancreas cages - clinic of a diabetes of I type, at smaller defeat β - cages insulin neediness proceeds is reserved also an embryo develops in a condition of exchange and immune infringements.

Under our data, defeat by viruses β - pancreas cages (in volume less than 70 %) and decrease in sensitivity of peripheral fabrics to insulin at young men leads to a schizophrenia. Insulinovaja neediness causes an Alzheimer's disease and an autism.

         The proof of the important role insulin neediness in development of syndromes of congenital anomalies is high frequency at mothers sick of a diabetes of a birth of children (to 10 %) with various developmental anomalies of cardiovascular system, a skeleton, neurologic infringements, besides high death rate in first two days of 8-18 %.

Our inspection in one of areas of Moscow of 53 children with congenital developmental anomalies (35 - heart diseases, 8 children with fenilcetonuria combined with олигофренией) has shown that the actual essential role is played by time of conception of the child. The most negative are the periods: 1.5 weeks to and 1.5 months after days of a spring and autumn equinox, and also a summer and winter solstice. In our opinion, the Sun during these periods makes active a slow and sharp infection, is thus damaged by a fruit gene. These periods also are characterised by the most frequent falling of planes of civil aircraft, social and military conflicts, technogenic accidents. (For these periods the Christian posts forbidding conception) are imposed.

Other alternative approach to preventive maintenance and treatment of the hereditary and congenital diseases, based on a principle of optimisation of the person in interspecific struggle for the biological niche is required.